Researchers from Georgia institute of technology have
developed a new technique called NANOBLASTS (cell punching) for
delivering small molecules,proteins and DNA directly in to living cells.
STEPS INVOLVED :
-Introducing Carbon
black particles of 25 nanometers in range in to fluid surrounding the
cells to which therapeutic agent has to be delivered.
-Bursts of near infra red
rays from a femto second laser are applied to fluid with carbon nano particles
at rate of 90 million pulses per second.
-Carbon nanoparticles absorb radiation from Near IR rays and become
hot.These hot particles in turn heat the surrounding fluid and form
steam.
s -This steam reacts with carbon nanoparticles to form carbon monoxide and Hydrogen.
5. -Two gases merge and form a bubble
which grows at expense of energy provided by Near IR rays from femto second
laser.
6. -Then Laser is turned off
suddenly.Now the bubble can’t grow due to non availability of energy.So
it collapses by creating a shock wave that punches holes in the membranes of
affected cells. The openings allow therapeutic agents from the
surrounding fluid to enter the cells. The holes quickly close so the cell can
survive.
Additional research and clinical trials will be needed
Before introducing this delivery technique in humans.
Authored by :
Imroz.S.M. M.pharm(pharmaceutics)
Contact mail id : imrozmpharm@gmail.com
References :
1.Sciencedaily.com
2.thedrugdeliveryblog.com
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