'Maceration' means 'softening'. The process is
normally used for the preparation of extracts ,tinctures and concentrated
infusions.
Types of Maceration
Keywords
Maceration,extracts ,tinctures ,concentrated infusions,marc,filtration,decantation
Authored by
S.M.Imroz , M.Pharm(Pharmaceutics) .,
Macertaion is
the simplest method of crude drug extraction.
Maceration Principle: The solid ingredients
are placed in a suitable container with suitable solvent (menstrum) and allowed
to stand for a period of 7 days with
frequent agitation, until soluble matter is dissolved.
Occasional
shaking brings rapid equilibrium between extra and inta cellular fluids
thereby bringing fresh men strum to the particle surface for extraction
The mixture is then strained (through nets / sieves), the solid residue (marc) is pressed and the combined liquids cleaned by filtration or by decantation, after standing.
The drug should
be properly minuted but fine powder
should be avoided as subsequent filtration becomes difficult.
Closed container is generally taken to reduce
the loss of solvents by evaporation
The drug is allowed to stand for few days
i) To help the solvent to penetrate the cells
of the drugs
ii) To provide the time for partitioning the
active ingredient into the solvent and
iii) To transfer the drug out of the cells into the bulk of the solvent. Frequent agitation is required to reduce the localized concentration around the cells and tissues.
iii) To transfer the drug out of the cells into the bulk of the solvent. Frequent agitation is required to reduce the localized concentration around the cells and tissues.
A. Simple maceration - a process for tinctures
made from organized drugs e.g. roots, stems, leaves etc.
B. Maceration with adjustment - a process for
tinctures made from unorganized drugs such as oleo-resins and gum resins.
C.
Multiple maceration - a process to prepare concentrated extract. It includes
‘Double maceration’ and ‘Triple maceration’
Keywords
Maceration,extracts ,tinctures ,concentrated infusions,marc,filtration,decantation
Authored by
S.M.Imroz , M.Pharm(Pharmaceutics) .,
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