Porphyrin was coated on the gold nanosurface via continuous stirring method. “Porphyrin gives the necessary protection and stability to the nanosurface.
The porphyrin molecule was found to be uniformly distributed on gold nanoparticles and the porphyrin–gold complex was stable.
The anti-tumour drug doxorubicin was then successfully loaded on the porphyrin–gold nanosurface. “Doxorubicin is selectively released when it reaches the low-pH environment seen in cancerous cells,” explains Kaushik Bera, research scholar at the institute and one of the first authors of the paper.
The porphyrin–gold complex without the drug showed no toxicity to healthy and cancerous cells. The nanoparticles coated with the drug showed very low toxicity to normal cells and caused programmed cell death both in brain and lung cancer cells.
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