Spherical Crystallization PPT
Spherical crystallization is a particle design technique,Spherical Crystallization PPT , Spherical crystallization process in detail:Spherical crystallization is a particle design technique, by which crystallization and agglomeration can be carried out simultaneously in one step.
Improves flowability and compressibility.
Crystalline forms of a drug to be converted into different polymorphic form having better bioavailability.
For masking of the bitter taste of drug.
General guide lines for the spherical agglomeration of drugs
Chow et al postulated some general guide lines for the spherical agglomeration of drugs
• For compounds that are water soluble, a water-immiscible organic solvent is used as the external medium and salt solutions of high concentration without common ions can be used as the bridging liquid.
• For compounds that are soluble in one or more organic solvents water is employed as the external phase and a water-immiscible organic solvent as the bridging liquid.
For compounds that are only soluble in water-miscible organic solvents a saturated aqueous solution of the compound can serve as the external phase and an organic solvent mixture as the bridging solvent.
• For compounds that are insoluble in water or any organic solvents a water-immiscible organic solvent can act as the external phase and a 20% calcium chloride solution as the bridging liquid. In addition, a binding agent such as PVP or PEG is required for agglomeration since the powders are not sufficiently soluble in the bridging liquids to allow binding through recrystallization and fusion.
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